Alzheimer’s pathophysiology
Alzheimer’s ailment is a modern dementia with lack of neurons and the presence of two foremost microscopic neuropathological hallmarks: extracellular amyloid plaques and intracellular neurofibrillary tangles. Early onset AD, a rare familial shape, is prompted due to mutation of 1 out of 3 genes: (amyloid precursor protein), (presenilin 2) or (presenilin 1). Sporadic shape takes place generally after age of 65 and bills for most instances; it maximum probable effects from a mixture of genetic and influence of surroundings. Confirmed hazard factors for sporadic AD are age and the presence of the E4 allele of (Apo lipoprotein E). Amyloid plaques contain specifically of the neurotoxic peptide amyloid (Aβ, Abeta), cleaved sequentially from a bigger precursor protein (APP) through two enzymes: β-secretase (also known as BACE1) and γ-secretase (comprising 4 proteins, presenilin is one in every of them). If APP is first cleaved by way of the enzyme α-secretase rather than β-secretase then Aβ isn't always fashioned. Neurofibrillary tangles contain especially of the protein tau which binds with microtubules, which facilitating the neuronal shipping system. Tau uncoupling from microtubules and aggregation into tangles inhibits transport and consequences in disassembly of microtubule. Phosphorylation of tau might have an crucial function on this. Selective vulnerability of neuronal structures which includes the cholinergic, serotonergic, and noradrenergic and glutamatergic systems form the premise of modern-day rational pharmacological remedy.
• Stem cells and Cell death
• Cellular signaling, kinases, phosphatases, calcium
• Cerebral Amyloid Angiopathy
• Tau Pathology of Alzheimers Disease
• Pathogenesis of Alzheimers Disease
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- Parkinson's Disease - Neurology Conference 2026 (France)
- Parkinson's Disease and Movement Disorders - Neurology Congress 2025 (France)
- Pathophysiology of Sleep Disorders - SLEEP DISORDER 2026 (Netherlands)
- Pediatric and Neonatal Viral Infections - Virology -2025 (France)
- Pediatric Applications & Ethical Considerations - CANNABIS MARIJUANA 2025 (Netherlands)
- Pediatric Neurology - Stroke Summit 2025 (UAE)
- Pediatric Neurology - NEUROSCIENCE_2025 (France)
- Pediatric Neurology - Brain Disorders-2025 (USA)
- Pediatric Neurology and Neurodevelopment - Neuropharmacology_2025 (UK)
- Pediatric Neurology: Developmental and Genetic Insights - Neurology Congress 2025 (France)
- Pediatric Neurosurgery - Child Neurology 2025 (UK)
- Pediatric Spine Disorders and Early Intervention Strategies - Spine 2025 (Italy)
- Personality and Mood Disorders - EURO MENTAL DISORDER 2026 (France)
- Pharmacological Treatments for Sleep Disorders - SLEEP DISORDER 2026 (Netherlands)
- Plant and Agricultural Virology - Virology -2025 (France)
- Post-Pandemic Mental Health Challenges - Mental Health Congress 2026 (France)
- Post-Viral Neuromuscular Syndromes and Long COVID - Neurology Conference 2026 (France)
- Precision Medicine and Genomics in Spinal Disorders - Spine 2025 (Italy)
- Psychedelic Psychiatry & Breakthrough Therapies - Mental Health Congress 2026 (France)
- Psychiatric Comorbidities in Neurological Disorders - Neurology Congress 2025 (France)
- Psychiatric Disorders - Neuroscience 2025 (France)
- Psychiatric Disorders - Neuroscience-2026 (UK)
- Psychiatric Disorders and Neurobiology - Brain Disorders-2025 (USA)
- Psychiatric Disorders and Psychopharmacology - Neuropharmacology_2025 (UK)
- Psychiatric neuroscience - Neuroscience Congress-2025 (France)
- Psychiatry - Neuroscience-2026 (UK)
- Psychiatry and Spirituality - Mental Health Congress 2026 (France)
- Psychiatry Mental health disorders - Neuro Experts 2025 (Canada)
- Psychology - Neuroscience-2026 (UK)
- Psychology, Cell & Molecular Biology - NEUROLOGY-2025 (Spain)
- Psychopharmacology - Neuroscience-2026 (UK)
- Psychosis - Neuro Experts 2025 (Canada)
- Psychosocial Aspects of Child Neurology - Child Neurology 2025 (UK)
- Psychotherapy and Evidence-Based Counseling - EURO MENTAL DISORDER 2026 (France)
- Public Health Initiatives and Advocacy - Alzheimers-2025 (France)
- Public Health, Policy, and Global Response - Virology -2025 (France)
- Regenerative Medicine and Stem Cell Therapy for Spinal Disorders - Spine 2025 (Italy)
- Regulatory Affairs & Legal Frameworks Worldwide - CANNABIS MARIJUANA 2025 (Netherlands)
- Rehabilitation and Neuroplasticity - NEUROSCIENCE_2025 (France)
- Rehabilitation and Restorative Therapy in Stroke - Stroke Summit 2025 (UAE)
- Respiratory Viruses and Pulmonary Infections - Virology -2025 (France)
- Restless Legs Syndrome and Periodic Limb Movement Disorder - SLEEP DISORDER 2026 (Netherlands)
- Risk factor and Prevention of Stroke - Stroke Summit 2025 (UAE)
- RNA and DNA Viruses - Virology -2025 (France)
- Role of Diet and Nutrition in Sleep Health - SLEEP DISORDER 2026 (Netherlands)
- Schizophrenia - Neuroscience Congress-2025 (France)
- Schizophrenia and psychotic disorders encompass - EURO MENTAL DISORDER 2026 (France)
- School-Based Mental Health Programs - Mental Health Congress 2026 (France)
- Sex, Gender, and Hormonal Influences in Neuro-Muscle Disorders - Neurology Conference 2026 (France)
- Sleep and Mental Health: Depression, Anxiety, and PTSD - SLEEP DISORDER 2026 (Netherlands)
- Sleep Deprivation: Cognitive, Emotional, and Physical Impacts - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorder - Neuroscience-2026 (UK)
- Sleep Disorders and Cardiometabolic Health - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorders and Chronobiology - Neuropharmacology_2025 (UK)
- Sleep Disorders and Circadian Neuroscience - NEUROSCIENCE_2025 (France)
- Sleep Disorders and Circadian Rhythm - NEURO CONGRESS 2025 (Canada)
- Sleep Disorders and Neuromodulation Techniques - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorders and Psychiatric Comorbidities - Mental Health Congress 2026 (France)
- Sleep Disorders and Their Neurological Implications - Neurology Congress 2025 (France)
- Sleep Disorders in Children and Adolescents - SLEEP DISORDER 2026 (Netherlands)
- Sleep Disorders in the Elderly - SLEEP DISORDER 2026 (Netherlands)
- Sleep Surgery and Oral Appliance Therapy - SLEEP DISORDER 2026 (Netherlands)
- Spinal Biomechanics and Kinesiology - Spine 2025 (Italy)
- Spinal Cord Injury: Advances in Treatment and Regeneration - Neurology Congress 2025 (France)
- Spinal Cord Stimulation and Neuromuscular Recovery - Neurology Conference 2026 (France)
- Spinal Deformities: Diagnosis and Treatment Innovations - Spine 2025 (Italy)
- Spinal Tumors: Diagnosis, Treatment, and Outcomes - Spine 2025 (Italy)
- Spine Disorders in the Aging Population: Challenges and Solutions - Spine 2025 (Italy)
- Sports-Related Spinal Injuries: Diagnosis, Prevention, and Treatment - Spine 2025 (Italy)
- Sports-Related Spine Injuries and Rehabilitation - Spine 2025 (Italy)
- Stem Cells & Brain Repair - Neuroscience 2025 (France)
- Stem Cells Role in Neuro-Biological Treatment - NEUROLOGY-2025 (Spain)
- Stem Cells Role in Neuro-Biological Treatment and Neurodermatology - Neurorehabilitation 2025 (Canada)
- Stigma and Advocacy in Mental Health - EURO MENTAL DISORDER 2026 (France)
- Stroke - Stroke Summit 2025 (UAE)
- Stroke & Neurological Disorders - Neuroscience 2025 (France)
- Stroke and Cerebrovascular Disorders - NEUROSCIENCE_2025 (France)
- Stroke and recovery - Neuroscience Congress-2025 (France)
- Suicide Prevention and Crisis Intervention - EURO MENTAL DISORDER 2026 (France)
- Suicide Prevention and Intervention Strategies - Mental Health Congress 2026 (France)
- Surgical Frontiers in Peripheral Nerve Injuries - Neurology Conference 2026 (France)
- Synthetic Virology and Genetic Engineering - Virology -2025 (France)
- Technology and Ethical Dilemmas in Psychiatry - Mental Health Congress 2026 (France)
- Telemedicine in Sleep Disorders Diagnosis and Care - SLEEP DISORDER 2026 (Netherlands)
- The Future of Spinal Robotics and Smart Wearable Technologies - Spine 2025 (Italy)
- The Impact of Space Travel and Microgravity on the Spine - Spine 2025 (Italy)
- The Intersection of Mental Health and Chronic Spine Disorders - Spine 2025 (Italy)
- The Role of Nutrition and Lifestyle in Spinal Health - Spine 2025 (Italy)
- Transcranial Magnetic Stimulation and Neuromuscular Plasticity - Neurology Conference 2026 (France)
- Trauma and Stressor-Related Disorders - EURO MENTAL DISORDER 2026 (France)
- Trauma-Informed Care and Global Crises - Mental Health Congress 2026 (France)
- Traumatic brain injury - Neuroscience Congress-2025 (France)
- Traumatic Brain Injury (TBI) - NEURO CONGRESS 2025 (Canada)
- Vaccines and Preventive Strategies - Virology -2025 (France)
- Viral Bioinformatics and Genomics - Virology -2025 (France)
- Viral Diagnostics and Biomarkers - Virology -2025 (France)
- Viral Epidemiology and Data Modeling - Virology -2025 (France)
- Viral Evolution and Adaptation - Virology -2025 (France)
- Viral Hepatitis and Liver Infections - Virology -2025 (France)
- Viral Immunology and Host Response - Virology -2025 (France)
- Viral Pathogenesis and Disease Mechanisms - Virology -2025 (France)
- Virtual Reality and Mixed Reality in Neurorehabilitation - Neurology Conference 2026 (France)
- Virus-Host Cell Interactions - Virology -2025 (France)
- Virus-Induced Autoimmunity and Chronic Conditions - Virology -2025 (France)
- Woman’s Mental Health - Neuro Experts 2025 (Canada)
- Women’s Health and Medical Cannabis - CANNABIS MARIJUANA 2025 (Netherlands)
- Women’s Mental Health - EURO MENTAL DISORDER 2026 (France)
- Workplace Mental Health and Burnout - Mental Health Congress 2026 (France)
- Yoga and Meditation - Neuro Experts 2025 (Canada)
- Young Researcher Forum & Emerging Investigators Track - CANNABIS MARIJUANA 2025 (Netherlands)
- Zoonotic and Vector-Borne Viruses - Virology -2025 (France)